Nalbun Injection 1ml

✔️ Uses of Nalbun Injection

Pain Relief

✔️ How does Nalbun Injection work?

Nalbun blocks pain signals, so the brain doesn't perceive the severity of pain, hence increasing the body's threshold for pain. 

✔️ Side Effects of Nalbun Injection

Commonly well tolerated but may include:

• Sedation
• Sweating
• Nausea
• Vomiting
• Dizziness
• Vertigo
• Dry mouth
• Headache
• Respiratory depression
• Dyspnea
• Asthma

✔️ Quick Suggestions:

• Use Nalbuphine as instructed by your doctor. Never take in greater amounts or more often than prescribed.
• It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
• Avoid consuming alcohol when taking the Nalbuphine, as it may cause excessive sleepiness or drowsiness.
• Inform your doctor if you have ever been diagnosed with kidney or liver problems.
• Store opioid pain relievers in a safe place and out of reach of others.

✔️ Indication of Nalbun Injection

Nalbuphine is used for moderate to severe pain.

✔️ Pharmacology

Nalbuphine Hydrochloride is a synthetic, potent analgesic with effects comparable to morphine. It functions primarily as a kappa agonist and partial mu antagonist. Key pharmacological properties include:

• Receptor Binding: Binds to mu, kappa, and delta receptors, but not sigma receptors.
• Onset of Action: 2 to 3 minutes after intravenous administration; less than 15 minutes after subcutaneous or intramuscular injection.
• Plasma Half-Life: Approximately 5 hours.
• Duration of Analgesic Activity: Ranges from 3 to 6 hours.

✔️ Dosage & Administration of Nalbun Injection

Adults:

Moderate to Severe Pain:

• 10-20 mg for a 70 kg patient, via intramuscular or intravenous injection.
• Adjust dosage based on pain severity, patient’s physical status, and other medications.
• Repeat every 3 to 6 hours as necessary.

Preoperative Anesthesia:

• 0.1-0.2 mg/kg via intravenous or intramuscular injection.

Obstetrical Analgesia (Labor & Delivery):

• 0.3-1 mg/kg via intravenous injection over 10-15 minutes.
• Maintenance doses of 0.25-0.5 mg/kg as needed.

Intraoperative Analgesia:

• 0.25-0.5 mg/kg via intravenous injection at 30-minute intervals.

Myocardial Infarction:

• 10-20 mg via slow intravenous injection.
• Repeat after 30 minutes if necessary.

Children (18 months to 15 years old):

• Analgesia:
  • 0.2 mg/kg body weight, preferably via intravenous or intramuscular injection.
  • Maintenance doses every 4 to 6 hours, as determined by a physician.

✔️ Interaction

• No hazardous interactions were identified specifically for Nalbun.
• Anticipated interactions include additive effects when combined with:
  • Narcotic analgesics
  • General anesthesia
  • Phenothiazines
  • Tranquilizers
  • Sedatives
  • Hypnotics
  • CNS depressants (including alcohol)

✔️ Contraindications

Known hypersensitivity to Nalbuphine Hydrochloride.

✔️ Pregnancy & Lactation

• Pregnancy Category B: High and rapid placental transfer. Use only if clearly needed.
• Lactation: Limited data suggest minimal excretion in maternal milk with no significant clinical effect. Exercise caution when administering to nursing women.

✔️ Precautions & Warnings

Use with caution in:

• Impaired respiration
• Impaired renal or hepatic function
• Biliary tract surgery
• Myocardial infarction
• Hypotension

✔️ Storage Conditions:

• Store below 30°C, protected from light.
• Keep out of reach of children.